Pachinko is a popular form of recreation in Japan. However, in recent years, along with Pachinko's popularity, "Pachinko dependence" has become topical news. The purpose of this study was to investigate beta-endorphin, catecholamines, immune system responses and heart rate during the playing of Pachinko. The following significant results were observed. (1) Plasma concentration of beta-endorphin increased before playing Pachinko and while in the Pachinko-center (p < 0.05). (2) Beta-endorphin and nor epinephrine increased when the player began to win (i.e. at "Fever-start") compared to baseline (p < 0.05). (3) Beta-endorphin, nor epinephrine and dopamine increased when the winning streak finished (i.e. at "Fever-end") compared to baseline (p < 0.05-0.01). (4) Nor epinephrine increased past 30 minutes after "Fever-end" compared to baseline (p < 0.05). (5) Heart rate increased before "Fever-start" compared to baseline, peaked at "Fever-start" and rapidly decreased to match rates measured at rest. But the increase was observed from 200 seconds after "Fever-start" (p < 0.05-0.001). (6) There was a positive correlation between the number of hours subjects played Pachinko in a week and the differences between beta-endorphin levels at "Fever-start" and those at rest (p < 0.05). (7) The number of T-cells decreased while the number of NK cells increased at "Fever-start" compared to baseline (p < .05). These results suggest that intracerebral substances such as beta-endorphin and dopamine are involved in the habit-forming behavior associated with Pachinko.
Introduction
Pachinko is a very popular form of recreation in Japan.
It is played in Pachinko parlors or centers which are large
halls containing row upon row of brightly colored
Pachinko machines. These machines are essentially a
combination of pinball and slot machine. Players pay for
large number of balls at 4 yen each. As in pinball, play
consists in controlling the speed with which each ball is
released into a complex arrangement of pins and gates.
When a ball enters the start gate this instructs the
machine to make a random selection of three numbers or
pictures. Similar to what appears in the window of a slot
machine, these numbers can be seen spinning on the
electronic display screen before coming to rest in a
sequence that may or may not signify a win. When a
player wins in this way the machine pays out Pachinko
balls which can either be fed back into play, or exchanged
for prizes, and ultimately for cash. Sometimes the player
will win more than 2,000 balls in a single jackpot. For the
purposes of our study, the most important point to grasp
is that when a player begins to win this can mark the start
of a series of consecutive pay-outs which can amount to a
considerable sum. This winning streak is known as
“Fever”, and comes to an end at a clearly defined moment
when the machine stops paying out.
According to “Leisure White Paper ’97” (Leisure
Development Center 1997), the population of Pachinko players in Japan had decreased slightly from 28,100,000
in 1987 to 27,400,000 in 1996. Total sales, however, had
risen to 24,366 billion yen from 11,602 billion yen. An
average Pachinko-player, therefore, that was spending
380,000 yen in 1987 increased his spending to 890,000
yen in 1996. These phenomena are thought to reflect the
increased perception of Pachinko as a form of gambling.
Actually, Pachinko has become a form of high-risk
gambling in which prizes or prize money can be obtained,
and a player may spend from 15,000 yen to 20,000 yen in
one hour’s playing. This phenomenon was brought to
national attention when some mothers, engrossed in
playing Pachinko, left their children in their car on an
unusually hot day and the children died. Thus so-called
“Pachinko-dependence” became a special news topic. We
hypothesized that there may be physiological changes
during the playing of Pachinko.
Yamada reported the appearance of FM theta waves
in one woman playing Pachinko (Yamada, 1997). Patkai
reported that epinephrine secretion increased during an
enjoyable game (Patkai, 1971). Furthermore, Yamada et
al. reported changes in electroencephalogram readings in
subjects playing TV games (Yamada et al., 1991, 1998).
But no model for investigating the physiological changes
in Pachinko players has yet been put forward.
During various types of exercise, plasma concentrations
of beta-endorphin increases (Mcmurray et al., 1987;
Michael et al., 1987, Sforzo, 1988) and this increase is
related to mood changes and “euphoria” (Markoff et al.,
1982; Janal et al., 1984, Kraemer, 1990). It has been
suggested that so-called experience of “running-high”
could be explained by these changes (Appenzeller, 1981;
Pargman and Baker, 1980). In addition, the habit of
smoking is known to reflect nicotine dependence (DSM
IV 1994). As nicotine induces dopamine secretion in the
“reward-axis” and motivates smoking behavior, nerve
chemical substances such as beta-endorphin modify the
affective states or cognitive demands of smokers
(Pomerleau 1992; Boyadjieva and Sarkar, 1997; Suh et al.,
1996).
Our main purpose was to investigate the changes in
beta-endorphin and catecholamines in Pachinko players.
Immune system responses and heart rate were also
investigated since the increase in beta-endorphin works
as an immunosuppressor, and also activates the immune
system (Northoff and Berg, 1991; Weicker and Werle,
1991), and norepinephrine secreted is correlated with
heart rate (Kondo et al., 1994)
Methods
Subjects and measurement
Six adult men (29–44 years old), who were regular
Pachinko players, were chosen as subjects. They agreed
to cooperate with the experiment, after being informed of
the purpose, contents, methods and risks. Betaendorphin (beta-end), epinephrine (EP), norepinephrine
(NE), dopamine (DA) levels, CD3, CD4, CD8, CD16,
CD56, and NK cell activity and heart rate were measured.
CD3-56 are Cell surface antigens (CD: Cluster
Determinants). CD 3 is the marker of T cell. CD 4 is the
marker of helper T cell. CD 8 is the marker of suppressor
T cell and that of killer T cell. CD 16 and CD 56 are the
markers of NK cell.
Heart rate
Heart rate was measured in a laboratory for baseline
setting. In the Pachinko-center, to measure modification
of cardiac frequency (fc), subjects were equipped with a
portable fc-recording apparatus (VHM 1-016, Bine
Co.with H-R and Interface type 2, Takei Co., Japan), and
a continuous recording of the player’s fc while in the
Pachinko-center was subsequently obtained for analysis
with a microcomputer system (PC-9801 VX NEC, Japan).
Blood
Blood was collected while subjects were sitting in a
chair in a laboratory (L). The next day subjects were
invited to play Pachinko with their own money in a
Pachinko-center (business as usual). They were asked to
play with so-called “Fever-machines”, but they could
freely choose their own favorite models. Blood was
collected from the subjects before they began playing in
the Pachinko-center (P), at Fever-start (FS), at Feverend (FE) and 30 minutes after Fever-end (A30).
Beta-endorphin and catecholamines
Beta-endorphin and catecholamines levels were
analyzed at points L through A30. For beta-endorphin
analysis blood was centrifuged immediately to serum and
analyzed using the RIA-method. Catecholamine levels
were determined using the HPLC-DPA-method.
Immune system substances
Immune system substances in blood were analyzed at
points L and FS.
CD, 3, 4, 8, 16 and 56 counts were analyzed using the
Flowsytometry-method. NK cell activity was analyzed
using the 51-Cr release method (beta-endorphin,
catecholamines, CD and NK cell activity were measured
by SRL Co., Japan).
Statistical Analysis
To calculate significance, paired t-tests were used.
The DA minimum used was 5 pg/ml. For cases measuring
below the minimum, DA values were represented as 5 pg/
ml, and Willcoxon signed-ranks tests were used.파칭코사이트인포 Results
Changes in beta-endorphin and catecholamines
The changes in beta-endorphin and catecholamines
levels are shown in Table 1. The level of beta-endorphin
secreted at P, at FS and at FE increased significantly
compared with that at L (p<0.05). DA secreted at FE